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Chronic kidney disease-related atherosclerosis - proteomic studies of blood plasma

Magdalena Luczak1, Dorota Formanowicz2, Elzbieta Pawliczak3, Maria Wanic-Kossowska3, Andrzej Wykretowicz4 and Marek Figlerowicz15*

Author Affiliations

1 Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland

2 Department of Clinical Biochemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland

3 Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland

4 Department of Internal Medicine, Division of Cardiology - Intensive Therapy, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland

5 Institute of Computing Science, Poznan University of Technology, Piotrowo 3A, 60-965 Poznan, Poland

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Proteome Science 2011, 9:25  doi:10.1186/1477-5956-9-25

Published: 13 May 2011

Additional files

Additional file 1:

Proteins identified in the plasma of CKD and CVD patients. This file provides information about the identified proteins: eg. MSDB/SwissProt accession number, MALDI score and sequence coverage. Spots corresponding to the particular numbers are shown in Figure 1.

Format: XLS Size: 21KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Differences between the relative accumulations of the differentially expressed proteins in all examined groups. p values were generated using unpaired Student's t-test (Statistica ver. 8.0). Differences identified as insignificant (p > 0.05) are bolded.

Format: XLS Size: 25KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Relative abundance (%vol) of proteins differentially expressed in HV and CKD groups. This file provides information about the relative abundance of the proteins differentially expressed in HV and CKD groups, In addition, it presents standard deviations and the results of unpaired Student's t-test generated using the Statistica ver. 8.0 software. Statistically insignificant results are bolded.

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

Relative abundance (%vol) of proteins differentially expressed in HV and CKD5 groups as well as in HV and CVD groups. This file provides information about the relative abundance of proteins differentially expressed in HV and CKD5 groups as well as in HV and CVD groups. In addition, it presents standard deviations and the results of unpaired Student's t-test generated using the Statistica ver. 8.0 software. Statistically insignificant results are bolded.

Format: XLS Size: 26KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

Statistical analysis of differences in α-1-m, apo-A-IV, Fb and Hp accumulation in plasma samples derived from patients treated or not treated with statin/IACE. P values were generated using unpaired Student's t-test (Statistica ver. 8.0). This file presents the final outcome of statistical analysis (p values) which was undertaken to determine whether the applied treatment affected the accumulation of differentially expressed proteins. P values were established individually for each protein in all studied groups of patients.

Format: XLS Size: 42KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data