Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury

Adrian Doroszko^1,5 , Thomas S Hurst² , Dorota Polewicz¹ , Jolanta Sawicka¹ , Justyna Fert-Bober¹ , David H Johnson³ and Grzegorz Sawicki^1,4

¹  Department of Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

²  Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

³  Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

⁴  Department of Clinical Chemistry, Medical University of Wroclaw, Wroclaw, Poland

⁵  On leave of absence from Department of Internal Medicine and Hypertension, Wroclaw Medical University, Wroclaw, Poland