Proteome analysis of human substantia nigra in Parkinson's disease

Cornelius J Werner¹^,2 , Roland Heyny-von Haussen³ , Gerhard Mall³ and Sabine Wolf⁴

¹Department of Neurology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany

²Institute of Neuroscience and Biophysics – Department of Medicine, Research Centre Juelich, 52425 Juelich, Germany

³Institute of Pathology, Klinikum Darmstadt, Grafenstrasse 9, 64283 Darmstadt, Germany

⁴Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry, Technical University Darmstadt, Petersenstrasse 22, 64285 Darmstadt, Germany

author email corresponding author email

Proteome Science 2008, 6:8doi:10.1186/1477-5956-6-8


Published:	14 February 2008

Additional files

Additional file 1:

Table of differentially expressed proteins. The following abbreviations are used: SSP = Standard Spot Number; (+) or (-) = over- and underexpression, respectively; MW = molecular weight; pI = isoelectric point; NCBI-Access.-Nr. = NCBI Accession number; Ratio = Ratio of PD positive/PD negative. Blue bar = average density of the Parkinson group, red bar = average density of the Control group. All proteins are significant with a p ≤ 0.05 (Mann-Whitney) uncorrected.

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Additional file 2:

Table of conserved and strictly-conserved proteins. The following abbreviations are used: SSP = Standard Spot Number; MW = molecular weight; pI = isoelectric point; NCBI-Access.-Nr. = NCBI Accession number; Asterisk (*) = difference of means ≤ 10% ("strictly-conserved"). Blue bar = average density of the Parkinson group, red bar = average density of the Control group.

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Additional file 3:

Standard Spot numbers (SSP), hit probabilities and MALDI-ToF-MS sequence coverages for all identified proteins. Additionally, mean densitometric values for each group are given as well as standard deviations and Mann-Whitney p-values. MW = molecular weight in kd; pI = isoelectric point; pT(%) = probability of a hit in percent; Score = MASCOT score; Cov(%) = sequence coverage in percent.

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