Figure 1.

Validation of dewarping using our approach. An overlay of chromatograms from 12 consecutive runs of a standard analyte mixture shows the small retention time shifts that were observed between runs (A). Reduction of variation in the retention times of each peak when the remaining peaks were aligned by dewarping, expressed as standard deviation in seconds (B), and as % changes in standard deviation (C), is also shown. Analytes that are labeled as UNK-1 and UNK-2 are unknown degradation products of the standard analytes.