Table 3

Nuclear differentially expressed proteins identification and regulation




hTERTt-WI38/WI38
 hTERT-WI38/HPV-WI38




Swiss-Prot AC
 Gene name, STRING protein association network legend
 Protein name
 Function
 T-test
 Regulation
 T-test
 Regulation
[P31943]
 HNRPH1
 Heterogeneous nuclear ribonucleoprotein H
 Pre-mRNAs processing
 4.4E-03
 1.73
 3.0E-02
 1.58
[P08235]
 NR3C2
 Mineralocorticoid receptor
 Binds to mineralocorticoid response elements (MRE) and transactivates target genes
 6.1E-03
 1.65
 1.6E-02
 1.53
[O14579]
 COPE
 Coatomer subunit epsilon
 Implicated in vesicles trafficking
 4.2E-02
 1.62
 0.12
 1.33
[Q05048]
 CSTF1
 Cleavage stimulation factor 50 kDa subunit
 Polyadenylation and 3'-end cleavage of mammalian pre-mRNAs
 1.5E-03
 1.57
 5.6E-03
 1.64
[P07900]
 HSPCA
 Heat shock protein HSP 90-alpha
 Chaperone, 680kDa human telomerase complex partner [72]
 1.5E-02
 1.42
 2.2E-04
 2.05
[P62826]
 ARA24
 GTP-binding nuclear protein Ran
 nucleocytoplasmic transport
 2.0E-02
 1.37
 6.7E-03
 1.24
[O43809]
 ENSP0000030 0291
 Cleavage and polyadenylation specificity factor 5
 Polyadenylation and 3'-end cleavage of mammalian pre-mRNAs
 1.6E-02
 1.35
 -
 1.35
[Q13838]
 ATP6V1G2
 splicesome RNA helicase BAT1
 Splice factor, required for mRNA export
 6.3E-03
 1.34
 1.7E-03
 1.5
[P25788]
 PSMA3
 Proteasome subunit alpha type 3
 Protein degradation
 5.6E-03
 0.68
 4.7E-02
 0.75
[P28072]
 PSMB6
 Proteasome subunit beta type 6 precursor
 Protein degradation
 3.8E-05
 0.65
 3.0E-04
 0.66
[P08865]
 RPSA
 40S ribosomal protein SA
 Protein synthesis
 1.3E-04
 0.58
 5.4E-04
 0.60
[P60842]
 EIF4A1
 Eukaryotic initiation factor 4A-I
 RNA helicase which mediates binding of mRNA to the ribosome
 3.1E-02
 0.54
 1.2E-01
 0.52
[P09382]
 LGALS1
 Galectin-1
 Cell growth, apoptosis and cell differentiation
 8.8E-07
 0.50
 1.2E-06
 0.51
[Q12906]
 ILF3
 Interleukin enhancer-binding factor 3
 Translation inhibitory protein of acid beta-glucosidase and other mRNAs, IL2 transcription regulator, promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA
 1.1E-05
 0.47
 9.5E-04
 0.66

List of the proteins differentially expressed due to hTERT transfection in the nuclear fraction of human WI38 cells. Listed by decreasing regulation.

Mazzucchelli et al. Proteome Science 2008 6:12   doi:10.1186/1477-5956-6-12