|
Forty statistically significant protein peaks are differentially expressed in normal and aneuploid AF samples |
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| Peak intensity (d) |
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|
|
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| m/z (a) |
Surface array |
p-value (b) |
AUC (c) |
Normal |
Aneuploidies |
Fold Change |
|
|
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| 6080 |
CM10 |
0.00001 |
0.918 |
1.66 |
9.50 |
5.7 |
| 2876 |
CM10 |
0.0006 |
0.861 |
6.37 |
20.96 |
3.3 |
| 15944 |
IMAC |
0.0013 |
0.838 |
4.12 |
1.99 |
0.5 |
| 3023 |
CM10 |
0.0015 |
0.837 |
10.06 |
27.88 |
2.8 |
| 7970 |
IMAC |
0.0016 |
0.833 |
4.78 |
2.67 |
0.6 |
| 6194 |
CM10 |
0.003 |
0.817 |
1.55 |
9.75 |
6.3 |
| 3903 |
IMAC |
0.0037 |
0.810 |
7.85 |
2.90 |
0.4 |
| 8455 |
CM10 |
0.0065 |
0.793 |
38.28 |
26.92 |
0.7 |
| 22214 |
CM10 |
0.0065 |
0.793 |
0.30 |
0.16 |
0.5 |
| 9626 |
IMAC |
0.0068 |
0.790 |
5.19 |
3.01 |
0.6 |
| 24720 |
Q10 |
0.0079 |
0.781 |
0.58 |
0.48 |
0.8 |
| 9467 |
IMAC |
0.0105 |
0.776 |
6.05 |
4.02 |
0.7 |
| 3173 |
Q10 |
0.0118 |
0.768 |
4.64 |
2.04 |
0.4 |
| 18977 |
IMAC |
0.012 |
0.771 |
0.61 |
0.29 |
0.5 |
| 4323 |
Q10 |
0.0134 |
0.763 |
5.66 |
9.47 |
1.7 |
| 5655 |
Q10 |
0.0134 |
0.763 |
5.47 |
2.92 |
0.5 |
| 14017 |
IMAC |
0.0137 |
0.767 |
4.82 |
2.65 |
0.5 |
| 3184 |
CM10 |
0.0151 |
0.764 |
2.93 |
8.41 |
2.9 |
| 3435 |
IMAC |
0.0157 |
0.762 |
2.66 |
9.04 |
3.4 |
| 8660 |
CM10 |
0.0172 |
0.760 |
4.95 |
3.00 |
0.6 |
| 9276 |
IMAC |
0.0178 |
0.757 |
1.90 |
4.11 |
2.2 |
| 12289 |
IMAC |
0.0178 |
0.757 |
4.97 |
3.33 |
0.7 |
| 15056 |
Q10 |
0.0194 |
0.750 |
0.78 |
1.31 |
1.7 |
| 3383 |
CM10 |
0.0196 |
0.755 |
7.24 |
12.71 |
1.8 |
| 13761 |
IMAC |
0.0202 |
0.752 |
6.15 |
4.10 |
0.7 |
| 7655 |
Q10 |
0.0245 |
0.741 |
4.52 |
6.56 |
1.5 |
| 14014 |
Q10 |
0.0245 |
0.741 |
4.56 |
2.72 |
0.6 |
| 11670 |
CM10 |
0.0251 |
0.744 |
3.19 |
1.92 |
0.6 |
| 4954 |
IMAC |
0.0259 |
0.743 |
14.73 |
10.19 |
0.7 |
| 7007 |
Q10 |
0.0275 |
0.737 |
3.85 |
1.98 |
0.5 |
| 6892 |
Q10 |
0.0308 |
0.732 |
4.34 |
3.26 |
0.8 |
| 8203 |
Q10 |
0.0308 |
0.732 |
5.80 |
3.45 |
0.6 |
| 9159 |
Q10 |
0.0308 |
0.732 |
9.03 |
7.82 |
0.9 |
| 11314 |
Q10 |
0.0344 |
0.728 |
6.90 |
4.10 |
0.6 |
| 8574 |
IMAC |
0.0367 |
0.729 |
12.48 |
7.55 |
0.6 |
| 4519 |
Q10 |
0.0472 |
0.714 |
1.44 |
2.27 |
1.6 |
| 4901 |
Q10 |
0.0472 |
0.714 |
3.61 |
2.25 |
0.6 |
| 13809 |
Q10 |
0.0472 |
0.714 |
4.20 |
2.73 |
0.6 |
| 49297 |
Q10 |
0.0472 |
0.714 |
0.21 |
0.16 |
0.8 |
| 11303 |
CM10 |
0.0499 |
0.716 |
2.62 |
1.90 |
0.7 |
|
a) m/z: mass/charge ratio of the protein peak. b) P-values were calculated using parametric Mann-Whitney test. c) AUC (area under the ROC curve) were calculated using normal amniotic fluids as reference. d) Averages of peak intensities. | ||||||
Mange et al. Proteome Science 2008 6:1 doi:10.1186/1477-5956-6-1 |
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