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Open Access Highly Accessed Review

Clinical proteomics and OMICS clues useful in translational medicine research

Elena López1*, Luis Madero2, Juan López-Pascual3 and Martin Latterich4*

Author Affiliations

1 Centro de Investigación i + 12, Hospital 12 de Octubre, Av. De Córdoba s/n, 28040, Madrid, Spain

2 Hospital Infantil Universitario Niño Jesús, Av. Menéndez Pelayo 65, 28009, Madrid, Spain

3 Hospital Universitario 12 de Octubre, Av. De Córdoba s/n, 28040, Madrid, Spain

4 Proteogenomics Research Institute for Systems Medicine, 11107 Roselle Street, San Diego, CA, 92121-1206, USA

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Proteome Science 2012, 10:35  doi:10.1186/1477-5956-10-35

Published: 29 May 2012

Abstract

Since the advent of the new proteomics era more than a decade ago, large-scale studies of protein profiling have been used to identify distinctive molecular signatures in a wide array of biological systems, spanning areas of basic biological research, clinical diagnostics, and biomarker discovery directed toward therapeutic applications. Recent advances in protein separation and identification techniques have significantly improved proteomic approaches, leading to enhancement of the depth and breadth of proteome coverage.

Proteomic signatures, specific for multiple diseases, including cancer and pre-invasive lesions, are emerging. This article combines, in a simple manner, relevant proteomic and OMICS clues used in the discovery and development of diagnostic and prognostic biomarkers that are applicable to all clinical fields, thus helping to improve applications of clinical proteomic strategies for translational medicine research.